Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin domain containing protein 3 (NLRP3) inflammasome is activated in response to a broad variety of cellular ...
A new narrative review maps the complex, context-dependent crosstalk between neurotransmitter systems and the NLRP3 ...
Northwestern Medicine investigators recently discovered that the mitochondrial respiratory chain — a series of protein complexes essential for a cellular respiration and energy production — is ...
SARS-CoV-2, which belongs to the family Coronaviridae, is a highly infectious virus that mainly infects the respiratory tract of humans. The viral genome of SARS-CoV-2 is found within the nucleocapsid ...
A team of researchers, affiliated with UNIST have unraveled the molecular mechanisms behind the activation of multiple inflammasomes and their role in inducing inflammatory cell death. This discovery ...
HY-209: a GPCR19 agonist inhibiting NLRP3 inflammasome activation as a potential therapeutic for atopic dermatitis Sep. 13, 2022 ...
In obese subjects at elevated cardiovascular disease (CVD) risk, MRT-8102, a NEK7-directed molecular glue degrader in development for the treatment of NLRP3/IL-1-driven inflammatory diseases, normaliz ...
A new class of anti-inflammatory drug is opening a world of possibilities for treating everything from neurological diseases to cancers. Using technology he developed at Hudson Institute of Medical ...
撰文丨王聪编辑丨王多鱼排版丨水成文营养状态与代谢稳态和炎症反应密切相关。然而，营养、代谢与炎症之间的直接机制联系，目前仍不清楚。2026 年 10 月 6 日，山东大学基础医学院高成江教授、刘峰副研究员等在 Nature 子刊 Nature ...
Comprendre une maladie rare, c’est souvent comprendre un mécanisme qui dépasse ce seul cas. Une équipe de l’Université de ...
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