Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

A new review in Molecular Biology Reports argues that DNA methylation silencing of the TRAIL pathway components DR5, DcR2, ...

Millions of people worldwide suffer from osteoporosis, a disease marked by progressive bone loss, weakened skeletal strength and increased fracture risk. Healthy bone is maintained through continuous ...

New in vitro research shows that free fatty acid–induced steatosis activates a TNF-α/TNFR1–Caspase−8/Caspase−2 apoptotic ...

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that ...

Discover the latest articles and news in related subjects. Apoptosis induction by infected cells is meant to jeopardize viral replication. Therefore, many viruses have developed strategies to inhibit ...

The pathological hallmark of Alzheimer’s disease (AD) is accumulation of misfolded amyloid-β peptides and hyperphosphorylated tau protein in the brain. Increasing evidence suggests that ...

St. Jude Children's Research Hospital scientists have identified previously unknown functions of the enigmatic enzyme caspase-6. The findings show that caspase-6 is a key regulator of innate immunity, ...

JEOLLANAM-DO, South Korea, July 24, 2026 /PRNewswire/ -- Millions of people worldwide suffer from osteoporosis, a disease marked by progressive bone loss, weakened skeletal strength, and increased ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

Expression profiles associated with disease progression in non-small cell lung cancer. Background: Cisplatin is a platinum-based chemotherapeutic drug used for treating a variety of human cancers such ...